Author Archives: admin1

Knowledge gaps that hamper prevention and control of Mycobacterium avium subspecies paratuberculosis infection

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Nearly a century of JD control programmes has, particularly in the dairy industry, not resulted in sufficient progress. Except for goats in Norway, no reports can be found in a herd in which MAP infection has been eradicated, and in many countries, herd- and animal-level prevalence has not decreased…

…Uptake of JD control programmes will improve if [the knowledge gaps identified by Barkema et al] have been satisfactorily addressed. However, because of the voluntary nature of JD programmes, it will still be important to identify factors that motivate farmers to enrol in these programmes.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/tbed.12723

May 2017

 

Research indicates MAP can withstand pasteurisation

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The phage-based test is said to have detected viable mycobacterium avium subspecies paratuberculosis (MAP) in 10.3% of the 386 samples of retail purchased pasteurised milk.

PBD Biotech CEO Dr Berwyn Clarke said: “We now have a new research tool at our fingertips that can rapidly detect the presence of MAP in all tissue and fluid at very high sensitivity, providing a real opportunity to improve our understanding of this mycobacteria and its associated diseases.”

Research indicates MAP can withstand pasteurisation

 

Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne’s Disease

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Published in November 2017,  this comprehensive and technical paper by Collins et al discusses the need for a highly efficacious live-attenuated vaccine capable of differentiating infected from vaccinated animals. It describes the potential link with Crohn’s disease and other human diseases which make MAP a concern as a zoonotic pathogen. It also references this website in describing the effect of MAP on the gut.

https://www.frontiersin.org/articles/10.3389/fvets.2017.00187/full

 

Introducing World MAP Day

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Announcing the launch of World MAP Day on 15th March: a day to spread awareness about Mycobacterium Avium subspecies Paratuberculosis (MAP). Read more about the highly successful pathogen called MAP – and why this special day was chosen here.

If you are a Facebook or Twitter user, you might also like to sign up for our Thunderclap message, scheduled to go out on social media platforms on 15th March at 7am. You can find the link here.

And if you are not on social media, please share news of World MAP Day in any way that you can.

Thank you.

The Crohn’s MAP Vaccine team

 

 

Increasing Incidence of Crohn’s Disease with Familial Clustering in the Kingdom of Bahrain: A 25-Year Population-based Study

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The incidence rate of Crohn’s disease in Bahrain is comparable to the U.S.A and has increased for men and women in all age groups. In this paper by Zayyani et al, Crohn’s disease clusters were common among families and included up to 3 generations consistent with presence of a common source or common genetic factors.

https://academic.oup.com/ibdjournal/article/23/2/304/4347190

 

Polymorphisms in Protein Tyrosine Phosphatase Non-receptor type 2 and 22 (PTPN2/22) are linked to hyper-proliferative T-Cells, and susceptibility to Mycobacteria in rheumatoid arthritis

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The data described by Naser et al in this recent paper suggest that genetic polymorphisms may play vital role in T-cell regulation, susceptibility to mycobacteria and ultimately response to treatment. This is the first study to report the detection of MAP DNA in the blood of RA patients; further studies are needed using larger number of samples.

 

https://www.frontiersin.org/articles/10.3389/fcimb.2018.00011/abstract