It’s all in the gut flora.
“This study indicates that MAP-infected cattle have a different composition of their fecal microbiota than MAP-negative cattle.”
August 2016
Author Archives: admin1
CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis
A study in mice by Suwandi et al, March 2017
“Here we provide clear evidence that recurrent exposure to MAP aggravates intestinal inflammation and clinical symptoms suggesting a disease promoting capability of MAP which might be of importance in JD and CD.
We provide conclusive evidence for the unique capacity of MAP to exacerbate DSS-mediated mucosal inflammation in the colon. We also identify the critical role of CD4+ T cells in this process consistent with their function in many other animal models of intestinal inflammation and human IBD.”
Resolution of Crohn’s (Johne ’s) disease with antibiotics: what are the next steps?
“The results of the survey and recent case reports of patients infected with MAP presenting with the clinical features of JD in cattle and CD in humans clearly show that MAP is a zoonotic pathogen.”
“A vaccine is needed to clear MAP from livestock and thereby the food stream. Antibiotic and other therapies are needed to treat humans infected with MAP who develop clinical disease.”
In this Feb 2017 paper Dr William Davis advocates a large trial of anti-MAP antibiotics on patients who are clearly infected with MAP, acknowledging that many of the parameters of the trial would necessarily overlap with those of the current RedHill trial, but that the proposed trial would afford the opportunity to fully evaluate current antibiotics and antibiotics under development.
http://www.tandfonline.com/doi/pdf/10.1080/17474124.2017.1300529
January 2017 Newsletter – Fundraising target achieved!
A very Happy New Year newsletter from Crohn’s MAP Vaccine!
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Mycobacterium paratuberculosis as a cause of Crohn’s disease.
Some noteworthy extracts from an October 2016 paper by McNees et al:
“Once thought to be an autoimmune disease, Crohn’s disease is currently thought to result from the interactions between environmental and genetic factors and persisting antigens [51]”
“The most commonly quoted frequency for detection of MAP is approximately 7 times more from Crohn’s disease patients than those with ulcerative colitis or normal controls [62].”
“The presence of MAP DNA in peripheral blood mononuclear cells from normal control patients also confirmed that humans are often exposed to MAP and that exposure is widespread [61,64]…..The fact that MAP can be found in individuals without Crohn’s disease does not exclude it as the cause of the disease.”
“Proof of causation requires more than similarity and association, no matter how strong. However, there are multiple strong associations between MAP and Crohn’s disease.”
Readers may also be interested in the paper cited in footnote 114, concerning virally vectored vaccines. The safety trial design is similar to our own. The article can be accessed here:-
Newsletter August 2016
Summer 2016 newsletter
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Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review
Although there are few epidemiologic data from developing countries, the incidence and prevalence of IBD are increasing with time and in different regions around the world, indicating its emergence as a global disease.
http://www.gastrojournal.org/article/S0016-5085(11)01378-3/fulltext
MAP in the Catchment Area and Water of the River Taff in South Wales, United Kingdom, and Its Potential Relationship to Clustering of Crohn’s Disease Cases in the City of Cardiff
“Data from several laboratories confirm that if the appropriate culture and PCR tests are done correctly, almost everyone with chronic inflammation of the gut of the Crohn’s disease type is found to be infected with this chronic enteric pathogen.” 2005 Pickup et al