Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne’s Disease

“Current vaccines cannot distinguish vaccinated from infected animals, thus compromising JD diagnostic tests (80), and strain 316F was generated in the 1920s by random attenuation procedures …. that are only now being investigated (81). In the final analysis, a vaccine of high efficacy is needed to significantly control JD (82).”