We believe there is compelling evidence pointing to MAP as the cause of Crohn’s Disease, a debilitating and aggressive form of Inflammatory Bowel Disease. MAP is proven to cause Johne’s Disease, a form of inflammatory bowel disease affecting domestic livestock. Johne’s Disease is strikingly similar to Crohn’s Disease. MAP is a type of bacteria: Mycobacterium avium subspecies paratuberculosis (MAP). It belongs to a family of bacteria called ‘Mycobacteria’, which also includes Tuberculosis and Leprosy. Prof Hermon-Taylor has developed a modern therapeutic vaccine against MAP, now it needs to be trialled to determine whether it can cure Crohn’s.
Historically, MAP in humans has been difficult to study as it cannot be seen under an ordinary microscope and is very difficult to grow. Testing for MAP by the presence of its DNA (using PCR) has found MAP in up to 92% of Crohn’s patients. Until now, no-one has developed a test to show MAP in-situ in the tissues of people with Crohn’s disease. With the new MAP test developed by Prof. Hermon-Taylor, we are seeing MAP in intricate detail for the very first time.
The test is an essential ‘companion diagnostic’ to the Vaccine trial; a simple blood test allowing doctors to confirm MAP infection prior to vaccination and to monitor patients’ responses to the vaccine. The completion of this final piece of the puzzle is currently under way at King’s College London, but funding is required to complete this vital work.
The Crohn’s MAP Vaccine is a modern, therapeutic Vaccine against MAP. Preliminary studies in animals have shown it is safe and effective. Now a trial in humans is needed to take the vaccine from lab to clinic.
© 2016 Professor John Hermon-Taylor. All rights reserved.